Category: Uncategorized
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Cleavable Vs. Non-Cleavable Linkers in ADCs
Antibody drug conjugates (ADCs) are a class of targeted cancer therapies that combine the specificity of monoclonal antibodies (mAbs) with the cytotoxic potency of small molecule drugs. These complex molecules consist of three components: the mAb, the cytotoxic drug, and the linker that connects them. The linker plays a critical role in ADCs as it…
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What is Polyethylene Glycol?
Polyethylene glycol (PEG) is a water-soluble polymer that has a wide range of applications in various industries.
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Ionizable Lipids in Drug Delivery
Success is earned, one step at a time. One of the most invaluable skills a person can have is being able to clearly express what they want. You have the courage that leads to success. As long as you’re learning, you’ll never fai In 2019 one of the greatest challenges in recent history emerged, COVID-19.…
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What are Antibody Drug Conjugates (ADC)?
Antibody drug conjugates (ADCs) are a type of targeted therapy used to treat cancer. They are made by combining a monoclonal antibody, a type of protein that specifically targets cancer cells, with a cytotoxic drug. The resulting ADC is designed to deliver the drug directly to cancer cells, minimizing the exposure of healthy tissues to…
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What are Multi-Charged Ionizable Lipids?
With the approval of mRNA vaccines to treat COVID, mRNA therapeutics are in use to treat a broad range of diseases. This influx of research puts forth the need to create better delivery materials. The formulation in both Moderna’s and Pfizer’s vaccines contains singly charged ionizable lipids. Moderna uses the lipid SM-102, and Pfizer uses…
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