Category: Drug discovery
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ADC Reduction & Conjugation Chemistry
Antibody drug conjugates (ADCs) are a type of targeted cancer therapy that combines the specificity of monoclonal antibodies with the potency of cytotoxic drugs. These innovative drugs have revolutionized the treatment of cancer by delivering potent drugs selectively to cancer cells, while sparing normal healthy cells from toxicity.
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Correlation between ionizable lipids selection and biodistribution
The development of mRNA vaccines has revolutionized the field of vaccination by offering a rapid response to infectious diseases, including COVID-19. These vaccines work by using messenger RNA (mRNA) to instruct cells to produce viral proteins, triggering an immune response to protect against the virus. However, the delivery of mRNA vaccines to the appropriate cells…
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What is Biotinylation?
Biotinylation is a process in which a biotin molecule is attached to a protein or other molecule. This chemical modification is widely used in molecular biology, biochemistry, and biotechnology for a variety of purposes. In this blog post, we will explore what biotinylation is, how it is done, and its applications.
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AI & Antibody Drug Conjugates (ADC)
Antibody drug conjugates (ADCs) are a promising class of therapeutics that combine the specificity of monoclonal antibodies with the potency of small molecule drugs. These conjugates are designed to target specific cancer cells and deliver a cytotoxic payload directly to the tumor, minimizing damage to healthy tissue. While ADCs have shown great potential, their development…
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Rotatable Bonds & Drug Development
Rotatable bonds are a critical factor in the design and development of drug molecules. In medicinal chemistry, the number of rotatable bonds in a molecule is an essential physicochemical property that affects its efficacy and pharmacokinetic properties. Rotatable bonds are single bonds that can freely rotate around their axis, which determines the molecule’s conformational flexibility.
Biotech Informers 